Could JC virus provoke metastasis in colon cancer?
AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects...
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Published in | World journal of gastroenterology : WJG Vol. 20; no. 42; pp. 15745 - 15749 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
14.11.2014
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Subjects | |
Online Access | Get full text |
ISSN | 1007-9327 2219-2840 2219-2840 |
DOI | 10.3748/wjg.v20.i42.15745 |
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Summary: | AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. |
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Bibliography: | Emanuele Sinagra;Dario Raimondo;Elena Gallo;Mario Stella;Mario Cottone;Ambrogio Orlando;Francesca Rossi;Emanuele Orlando;Marco Messina;Giovanni Tomasello;Attilio Ignazio Lo Monte;Ennio La Rocca;Aroldo Gabriele Rizzo;Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele-G Giglio, Contrada Pietra Pollastra Pisciotto;course in Surgical Biotechnology and Regenerative Medicine, University of Palermo;Euro-Mediterranean Institute of Science and Technology (IEMEST);Unit of Pathology, Ospedali Riuniti Villa Sofia - Cervello, University of Palermo;DIBIMIS, Unit of Internal Medicine, Ospedali Riuniti Villa Sofia - Cervello, University of Palermo;Oncology Unit, Fondazione Istituto San Raffaele-G Giglio, Contrada Pietra Pollastra Pisciotto;Department of Surgical and Oncological Disciplines, School of Medicine, University of Palermo;Unità Operativa di Medicina interna e trapiantologia, Ospedale San Raffaele ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Emanuele Sinagra, MD, Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele-G Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy. emanuelesinagra83@googlemail.com Author contributions: Sinagra E wrote the paper; Gallo E and Rizzo AG designed the project of the study; Stella M collected the pathological data; Orlando E, Rossi F, Tomasello G and Messina M collected the clinical data; Orlando A, Raimondo D, La Rocca E and Lo Monte AI, Cottone M revised critically the manuscript. Telephone: +39-921-920712 Fax: +39-921-920406 |
ISSN: | 1007-9327 2219-2840 2219-2840 |
DOI: | 10.3748/wjg.v20.i42.15745 |