Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies

• Published in: Annals of oncology Vol. 23; no. 6; pp. 1394 - 1402
• Main Authors: Aune, D., Chan, D.S.M., Greenwood, D.C., Vieira, A.R., Rosenblatt, D.A. Navarro, Vieira, R., Norat, T.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2012; Oxford University Press
• Subjects: Antineoplastic agents; Biological and medical sciences; Breast cancer; Breast Neoplasms - prevention & control; Cancer; cancer prevention; Diet; dietary fiber; Dietary Fiber - administration & dosage; Diets; Dose-Response Relationship, Drug; Edible Grain; Female; Fibers; Fruit; Fruits; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; meta-analysis; Pharmacology. Drug treatments; Prospective Studies; Reviews; Risk; Tumors; Vegetables; meta-analysis; breast cancer; diet; cancer prevention; dietary fiber; Breast disease; Nutrition; Systematic review; Breast cancer; Review; Malignant tumor; Feeding; Metaanalysis; Prospective; Prevention; Mammary gland diseases; Diet; Risk factor; Dietary fiber; Cancer; Food
• ISSN: 0923-7534; 1569-8041; 1569-8041
• DOI: 10.1093/annonc/mdr589

Evidence from case–control studies suggest that dietary fiber may be inversely related to breast cancer risk, but it is unclear if this is supported by prospective data. We conducted a systematic review and meta-analysis of the evidence from prospective studies. PubMed was searched for prospective studies of fiber intake and breast cancer risk until 31st August 2011. Random effects models were used to estimate summary relative risks (RRs). Sixteen prospective studies were included. The summary RR for the highest versus the lowest intake was 0.93 [95% confidence interval (CI) 0.89–0.98, I2 = 0%] for dietary fiber, 0.95 (95% CI 0.86–1.06, I2 = 4%) for fruit fiber, 0.99 (95% CI 0.92–1.07, I2 = 1%) for vegetable fiber, 0.96 (95% CI 0.90–1.02, I2 = 5%) for cereal fiber, 0.91 (95% CI 0.84–0.99, I2 = 7%) for soluble fiber and 0.95 (95% CI 0.89–1.02, I2 = 0%) for insoluble fiber. The summary RR per 10 g/day of dietary fiber was 0.95 (95% CI 0.91–0.98, I2 = 0%, Pheterogeneity = 0.82). In stratified analyses, the inverse association was only observed among studies with a large range (≥13 g/day) or high level of intake (≥25 g/day). In this meta-analysis of prospective studies, there was an inverse association between dietary fiber intake and breast cancer risk.