A new modification for mammalian messenger RNA

The discovery of multiple RNA modifications in the past few years has broadened our views of the structures and potential functions of RNA species, but deciphering which modifications are made where and how remains a challenge. A new study by Xu et al. applies a combination of mass spectrometry, bio...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 292; no. 35; pp. 14704 - 14705
Main Authors Liu, Fange, He, Chuan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2017
American Society for Biochemistry and Molecular Biology
Subjects
Animals
Editors' Picks Highlights
Methyltransferases - genetics
RNA - chemistry
RNA Processing, Post-Transcriptional
RNA, Messenger - chemistry
RNA, Transfer
Online AccessGet full text

Cover

More Information
Summary:The discovery of multiple RNA modifications in the past few years has broadened our views of the structures and potential functions of RNA species, but deciphering which modifications are made where and how remains a challenge. A new study by Xu et al. applies a combination of mass spectrometry, biochemistry, genetics, and cellular biology tools to reveal the two mammalian methyltransferases that are responsible for m3C installation in tRNA and a third that mediates the previously unknown installation of m3C in mammalian mRNA.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
Edited by Xiao-Fan Wang
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.H117.798298