Methylation multiplicity and its clinical values in cancer

Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes and is associated with diverse differentiation events, physiological activities and human diseases. To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provi...

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Bibliographic Details
Published inExpert reviews in molecular medicine Vol. 23; p. e2
Main Authors Dai, Xiaofeng, Ren, Tiejun, Zhang, Yuxin, Nan, Nan
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 31.03.2021
Subjects
Deoxyribonucleic acid
DNA
DNA methylation
Enzymes
Epigenetics
Gene expression
Localization
Mammals
Proteins
Review
Roles
Signal transduction
Transfer RNA
Writers
early diagnosis
DNA methylation
protein methylation
RNA methylation
Cancer
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Summary:Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes and is associated with diverse differentiation events, physiological activities and human diseases. To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provides a boutique yet comprehensive overview on methylation at different levels including the mechanisms, cross-talking and clinical implications with a particular focus on cancers. We conclude that DNA methylation is the sole type of methylation that has been largely translated into clinics and used for, mostly, early diagnosis. Translating the onco-therapeutic and prognostic values of RNA and protein methylations into clinical use deserves intensive efforts. Simultaneous examination of methylations at multiple levels or together with other forms of molecular markers represents an interesting research direction with profound clinical translational potential.
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Both authors contributed equally.
ISSN:1462-3994
1462-3994
DOI:10.1017/erm.2021.4