Pharmacological Strategies for Overcoming Multidrug Resistance to Chemotherapy

Actual mechanisms of multidrug resistance (MDR) to chemotherapy in oncology are considered. ABC-transporters such as P-glycoprotein, BCRP protein, and MRP proteins take part in the development of resistance. The review presents the main classes of chemosensitizers, i.e., inhibitors of ABC transporte...

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Published inPharmaceutical chemistry journal Vol. 56; no. 10; pp. 1307 - 1313
Main Authors Fedotcheva, T. A., Shimanovsky, N. L.
Format Journal Article
LanguageEnglish
Published New York Springer US 2023
Springer
Subjects
Cancer
Chemotherapy
Drug resistance in microorganisms
Isoflavones
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polyphenols
Proteins
P-glycoprotein
tyrosine kinase inhibitors
multidrug resistance
MRP proteins
flavonoids
BCRP-protein
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Summary:Actual mechanisms of multidrug resistance (MDR) to chemotherapy in oncology are considered. ABC-transporters such as P-glycoprotein, BCRP protein, and MRP proteins take part in the development of resistance. The review presents the main classes of chemosensitizers, i.e., inhibitors of ABC transporters of the 1 st -4 th generations. Plant polyphenols, i.e., flavonoids, are commonly referred to as the last (4 th ) generation of MDR inhibitors. Chemosensitizers of different classes should be chosen with allowance for the patient mutation-expression profile and the receptor status of a particular tumor. The appropriate dosage of the chemosensitizer and the administration schedule can enhance the process of counteracting MDR.
Bibliography:ObjectType-Article-1
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ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-02790-8