A Conformational Change of C Fragment of Tetanus Neurotoxin Reduces Its Ganglioside-Binding Activity but Does Not Destroy Its Immunogenicity

• Published in: Clinical and Vaccine Immunology Vol. 18; no. 10; pp. 1668 - 1672
• Main Authors: Yu, Rui, Yi, Shaoqiong, Yu, Changming, Fang, Ting, Liu, Shuling, Yu, Ting, Song, Xiaohong, Fu, Ling, Hou, Lihua, Chen, Wei
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2011
• Subjects: Animals; Antitoxins - blood; Cell Line; Disulfides; Gangliosides - metabolism; Immunoglobulin G - blood; Metalloendopeptidases - chemistry; Metalloendopeptidases - immunology; Metalloendopeptidases - metabolism; Metalloendopeptidases - toxicity; Mice; Mice, Inbred BALB C; Protein Conformation; Rats; Survival Analysis; Tetanus - prevention & control; Tetanus Toxin - chemistry; Tetanus Toxin - immunology; Tetanus Toxin - metabolism; Tetanus Toxin - toxicity; Tetanus Toxoid - adverse effects; Tetanus Toxoid - chemistry; Tetanus Toxoid - immunology; Tetanus Toxoid - metabolism; Toxoids - chemistry; Toxoids - immunology; Toxoids - metabolism; Toxoids - toxicity; Vaccine Research
• ISSN: 1556-6811; 1556-679X; 1556-679X
• DOI: 10.1128/CVI.05244-11

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