Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction

• Published in: Journal of clinical medicine Vol. 10; no. 19; p. 4326
• Main Authors: Cottin, Yves, Issa, Rany, Benalia, Mourad, Mouhat, Basile, Meloux, Alexandre, Tribouillard, Laura, Bichat, Florence, Rochette, Luc, Vergely, Catherine, Zeller, Marianne
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.09.2021; MDPI
• Subjects: Age; Atherosclerosis; Biomarkers; Brief Report; Calcification; Cardiology and cardiovascular system; Cardiovascular disease; Clinical medicine; Coronary vessels; Creatinine; Diabetes; Heart failure; Human health and pathology; Hypertension; Life Sciences; Ligands; Medical imaging; Mortality; Smooth muscle; Tumor necrosis factor-TNF; coronary artery disease; SYNTAX score; osteoprotegerin; myocardial infarction; vascular calcification
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm10194326

Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3-6)), medium (11 (9-13)) and high (20 (18-23)) tertiles of SYNTAX score. Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782-1497), 1240 (870-1707), and 1464 (1011-2129) pg/mL, respectively ( < 0.001)). In multivariate analysis, OPG [OR(CI95%): 2.10 (1.29-3.49) 0.003], were associated with the high SYNTAX group, beyond hypercholesterolemia, CV history and reduced glomerular filtration rate. We found an association between OPG levels and coronary lesions complexity patients with acute MI.