Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement

Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valv...

Full description

Saved in:
Bibliographic Details
Published inJACC. Basic to translational science Vol. 8; no. 11; pp. 1424 - 1435
Main Authors Lassalle, Fanny, Duployez, Nicolas, Vincent, Flavien, Rauch, Antoine, Denimal, Tom, Rosa, Mickael, Labreuche, Julien, Dombrowicz, David, Staels, Bart, Preudhomme, Claude, Susen, Sophie, Van Belle, Eric, Dupont, Annabelle
Format Journal Article
LanguageEnglish
Published United States Elsevier on behalf of the American College of Cardiology Foundation 01.11.2023
Elsevier
Subjects
Cardiology and cardiovascular system
Human health and pathology
Life Sciences
Original Research - Clinical
clonal hematopoiesis
aortic valve stenosis
transcatheter aortic valve replacement
survival
Online AccessGet full text

Cover

More Information
Summary:Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and assessed their association with long-term survival after TAVR. One or several CHIP variants in 35 genes were identified in 68% of the cohort, and being the 2 most frequently mutated genes. Patients carrying a -CHIP-driver variant with low variant allele frequency (2%-10%) had a significant decrease in overall survival 5 years after TAVR.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2023.04.010