Laser spectroscopic technique for direct identification of a single virus I FASTER CARS

From the famous 1918 H1N1 influenza to the present COVID-19 pandemic, the need for improved viral detection techniques is all too apparent. The aim of the present paper is to show that identification of individual virus particles in clinical sample materials quickly and reliably is near at hand. Fir...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 117; no. 45; pp. 27820 - 27824
Main Authors Deckert, Volker, Deckert-Gaudig, Tanja, Cialla-May, Dana, Popp, Jürgen, Zell, Roland, Deinhard-Emmer, Stefanie, Sokolov, Alexei V., Yi, Zhenhuan, Scully, Marlan O.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 10.11.2020
Subjects
Atomic force microscopy
Coherent scattering
COVID-19
Influenza
Lasers - standards
Limit of Detection
Microscopy, Atomic Force - instrumentation
Microscopy, Atomic Force - methods
Pandemics
Physical Sciences
Raman spectra
SARS-CoV-2 - ultrastructure
Spectrum Analysis, Raman - instrumentation
Spectrum Analysis, Raman - methods
Time
Virion - ultrastructure
Virions
Viruses
virus detection
coherent anti-Stokes Raman scattering (CARS)
tip-enhanced Raman scattering (TERS)
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ISSN0027-8424
1091-6490
1091-6490
DOI10.1073/pnas.2013169117

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Summary:From the famous 1918 H1N1 influenza to the present COVID-19 pandemic, the need for improved viral detection techniques is all too apparent. The aim of the present paper is to show that identification of individual virus particles in clinical sample materials quickly and reliably is near at hand. First of all, our team has developed techniques for identification of virions based on a modular atomic force microscopy (AFM). Furthermore, femtosecond adaptive spectroscopic techniques with enhanced resolution via coherent anti-Stokes Raman scattering (FASTER CARS) using tip-enhanced techniques markedly improves the sensitivity [M. O. Scully, et al., Proc. Natl. Acad. Sci. U.S.A. 99, 10994–11001 (2002)].
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Reviewers: F.C., Harvard University; D.R.H., Texas A&M University–College Station; and H.E.S., Boston University.
Author contributions: V.D. and M.O.S. designed research; V.D., T.D.-G., D.C.-M., J.P., and A.V.S. performed research; D.C.-M., J.P., R.Z., S.D.-E., and A.V.S. contributed new reagents/analytic tools; V.D., T.D.-G., D.C.-M., J.P., R.Z., S.D.-E., A.V.S., Z.Y., and M.O.S. analyzed data; and V.D., T.D.-G., A.V.S., Z.Y., and M.O.S. wrote the paper.
Contributed by Marlan O. Scully, August 17, 2020 (sent for review July 1, 2020; reviewed by Federico Capasso, Dudley Robert Herschbach, and H. Eugene Stanley)
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.2013169117