Cytocapsular tubes conduct cell translocation
Cell locomotion is essential for multicellular organism embryo development, organ homeostasis, tissue regeneration, immune responses, and tumor metastasis. Here we report that single mammalian cells can generate two extracellular membranous compartments: cytocapsulae and cytocapsular tubes. Cells mi...
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Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 6; pp. E1137 - E1146 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences
06.02.2018
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Series | PNAS Plus |
Subjects | |
Online Access | Get full text |
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Summary: | Cell locomotion is essential for multicellular organism embryo development, organ homeostasis, tissue regeneration, immune responses, and tumor metastasis. Here we report that single mammalian cells can generate two extracellular membranous compartments: cytocapsulae and cytocapsular tubes. Cells migrate in cytocapsulae and engender cytocapsular tubes, which exhibit pleiotropic biological functions and provide tubular routes for directed cell transportation. Ultrastructural analysis by electron microscope revealed that nanoprotrusions surround and anchor cytocapsular tubes in place. Multiple cytocapsular tubes interconnect and form networks supporting directed cell transportation in diverse directions. Enhanced translation initiation factor eIF4E upregulates translation of transcripts encoding proteins important for organelle development. Thus, this study proposes a mechanism of directed cell translocation in cytocapsular tubes, which may facilitate the management of diseases, including tumor metastasis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: T.Y. and G.W. designed research; T.Y. performed research; T.Y. analyzed data; and T.Y. and G.W. wrote the paper. Contributed by Gerhard Wagner, December 20, 2017 (sent for review October 13, 2017; reviewed by Davide Ruggero and Nahum Sonenberg) Reviewers: D.R., University of California, San Francisco; and N.S., McGill University. |
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.1717910115 |