Antidiabetic activity of Terminalia catappa Linn fruits

• Published in: Journal of ethnopharmacology Vol. 88; no. 1; pp. 45 - 50
• Main Authors: Nagappa, A.N., Thakurdesai, P.A., Venkat Rao, N., Singh, Jiwan
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.2003; Elsevier
• Subjects: Alloxan - adverse effects; Alloxan - blood; Alloxan-induced diabetes; Animals; Antidiabetic activity; Biological and medical sciences; Blood Glucose - drug effects; Body Weight - drug effects; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - drug therapy; Fruit; General pharmacology; Glyburide - therapeutic use; Hypoglycemic Agents - therapeutic use; India; Islets of Langerhans - drug effects; Islets of Langerhans - pathology; Medical sciences; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Photomicrography; Phytotherapy; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Terminalia; Terminalia catappa Linn fruit; Time Factors; Asia; India; Antidiabetic activity; Alloxan-induced diabetes; Terminalia catappa Linn fruit; Fruit; Rat; Diabetes mellitus; Rodentia; Extract; Medicinal plant; Vertebrata; Hypoglycemic agent; Experimental disease; Mammalia; Combretaceae; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(03)00208-3

In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic and aqueous extracts which were earlier, necrosed by alloxan.