Association of the Clínica Universidad de Navarra-Body Adiposity Estimator With Type 2 Diabetes: A Retrospective Cohort Study

• Published in: International journal of public health Vol. 68; p. 1606063
• Main Authors: Geng, Shuoji, Chen, Xuejiao, Bai, Kaizhi, Ding, Jiacheng, Li, Haojie, Shi, Songhe
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 21.09.2023
• Subjects: body mass index; CUN-BAE; middle-aged and older adults; Public Health Archive; type 2 diabetes mellitus; waist circumference
• ISSN: 1661-8564; 1661-8556; 1661-8564
• DOI: 10.3389/ijph.2023.1606063

Objectives: Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) is considered to be a more accurate indicator of body fat estimation. We aimed to investigate the association of CUN-BAE with the risk of type 2 diabetes mellitus (T2DM) and to compare the strength of the association between CUN-BAE, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and T2DM. Methods: The data were obtained from the annual health checkup database of residents in Xinzheng, China. From January 2011 to December 2021, 80,555 subjects aged ≥45 years met the inclusion criteria. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CUN-BAE, BMI, WC, and WHtR in T2DM. Results: During a mean follow-up of 6.26 years, T2DM occurred in 12,967 subjects. The multivariable-adjusted HRs (95% CIs) of T2DM (highest vs. reference group) were 1.994 (1.811–2.196) for CUN-BAE, 1.751 (1.665–1.842) for WC, 1.715 (1.631–1.804) for WHtR, and 1.510 (1.436–1.588) for BMI, respectively. In addition, the risk of T2DM increased with baseline CUN-BAE (HR: 1.374; 95% CI: 1.328, 1.421), WC (HR: 1.236; 95% CI: 1.215, 1.256), WHtR (HR: 1.228; 95% CI: 1.208, 1.248), and BMI (HR: 1.175; 95% CI: 1.156, 1.195). Conclusion: Compared to BMI, WC or WHtR, CUN-BAE may more adequately reflect the adverse effects of adiposity on the risk of T2DM.