Stool-Based Pathogen Detection Offers Advantages as an Outcome Measure for Water, Sanitation, and Hygiene Trials

Most health impact trials of water, sanitation, and hygiene use caregiver-reported diarrhea in children as the primary outcome; this measure is known to be subject to considerable bias, especially when used in unblinded trials. Detection of enteric pathogens in stool or fecal waste via multiplex mol...

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 102; no. 2; pp. 260 - 261
Main Authors Brown, Joe, Cumming, Oliver
Format Journal Article
LanguageEnglish
Published United States Institute of Tropical Medicine 01.02.2020
The American Society of Tropical Medicine and Hygiene
Subjects
Caregivers
Diarrhea
Feces - microbiology
Humans
Hygiene - standards
Outcome Assessment, Health Care
Pathogens
Pieces
Sanitation
Sanitation - standards
Water Quality - standards
Water Supply - standards
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Summary:Most health impact trials of water, sanitation, and hygiene use caregiver-reported diarrhea in children as the primary outcome; this measure is known to be subject to considerable bias, especially when used in unblinded trials. Detection of enteric pathogens in stool or fecal waste via multiplex molecular methods may offer advantages over—and is complementary to—caregiver-reported diarrhea because these measures are objective, on the causal pathway from exposures of interest to disease outcomes, and increasingly feasible in high-burden countries.
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Authors’ addresses: Joe Brown, School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, E-mail: joe.brown@ce.gatech.edu. Oliver Cumming, Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, E-mail: oliver.cumming@lshtm.ac.uk.
ISSN:0002-9637
1476-1645
1476-1645
DOI:10.4269/ajtmh.19-0639