Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice

Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). We evaluated the anti-inf...

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Published inJournal of ethnopharmacology Vol. 144; no. 1; pp. 94 - 100
Main Authors Sung, Yoon-Young, Kim, Dong-Seon, Yang, Won-Kyung, Nho, Kyoung Jin, Seo, Hyeong Seok, Kim, Young Sang, Kim, Ho Kyoung
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 31.10.2012
Subjects
Allergens - immunology
Animals
Anti-inflammatory
anti-inflammatory activity
Anti-Inflammatory Agents - therapeutic use
Antigens, Dermatophagoides
atopic dermatitis
Cytokines - blood
Cytokines - genetics
Dermatitis, Atopic - blood
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - pathology
Dermatophagoides farinae - immunology
Drynaria
Drynaria fortunei
dust
dust mites
ears
ethanol
gene expression
histopathology
hyperlipidemia
IgE
IL-6
immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G - blood
interleukin-4
interleukin-6
Male
messenger RNA
Mice
NC/Nga mouse
necrosis
Phytotherapy
Plant Extracts - therapeutic use
Polypodiaceae
Rhizome
skin lesions
traditional medicine
tumor necrosis factor-alpha
Anti-inflammatory
IgE
NC/Nga mouse
IL-6
Drynaria fortunei
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Abstract Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment. DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD. The anti-inflammatory and anti-allergic effects of Drynaria fortunei extract (DFE) on house dust mite Dermatophargoides farinae-induced atopic dermatitis model were evaluated by dermatitis score, ear thicknesses and histopathological analysis. DFE treatment significantly decreased the dermatitis score, ear swelling, dermis/epidermis thickening, and mast cell accumulation in the dermis of NC/Nga mice. [Display omitted]
AbstractList Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment. DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD.
ETHNOPHARMACOLOGICAL RELEVANCEDrynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE).MATERIALS AND METHODSWe evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice.RESULTSTreatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment.CONCLUSIONSDFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD.
Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment. DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD. The anti-inflammatory and anti-allergic effects of Drynaria fortunei extract (DFE) on house dust mite Dermatophargoides farinae-induced atopic dermatitis model were evaluated by dermatitis score, ear thicknesses and histopathological analysis. DFE treatment significantly decreased the dermatitis score, ear swelling, dermis/epidermis thickening, and mast cell accumulation in the dermis of NC/Nga mice. [Display omitted]
ETHNOPHARMACOLOGICAL RELEVANCE: Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). MATERIALS AND METHODS: We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. RESULTS: Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment. CONCLUSIONS: DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD.
Author Sung, Yoon-Young
Kim, Young Sang
Kim, Ho Kyoung
Seo, Hyeong Seok
Yang, Won-Kyung
Kim, Dong-Seon
Nho, Kyoung Jin
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Keywords Anti-inflammatory
IgE
NC/Nga mouse
IL-6
Drynaria fortunei
Language English
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Snippet Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism,...
ETHNOPHARMACOLOGICAL RELEVANCE: Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia,...
ETHNOPHARMACOLOGICAL RELEVANCEDrynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia,...
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SubjectTerms Allergens - immunology
Animals
Anti-inflammatory
anti-inflammatory activity
Anti-Inflammatory Agents - therapeutic use
Antigens, Dermatophagoides
atopic dermatitis
Cytokines - blood
Cytokines - genetics
Dermatitis, Atopic - blood
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - pathology
Dermatophagoides farinae - immunology
Drynaria
Drynaria fortunei
dust
dust mites
ears
ethanol
gene expression
histopathology
hyperlipidemia
IgE
IL-6
immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G - blood
interleukin-4
interleukin-6
Male
messenger RNA
Mice
NC/Nga mouse
necrosis
Phytotherapy
Plant Extracts - therapeutic use
Polypodiaceae
Rhizome
skin lesions
traditional medicine
tumor necrosis factor-alpha
Title Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice
URI https://dx.doi.org/10.1016/j.jep.2012.08.035
https://www.ncbi.nlm.nih.gov/pubmed/22964469
https://search.proquest.com/docview/1112342412
Volume 144
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