Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice

• Published in: Journal of ethnopharmacology Vol. 144; no. 1; pp. 94 - 100
• Main Authors: Sung, Yoon-Young, Kim, Dong-Seon, Yang, Won-Kyung, Nho, Kyoung Jin, Seo, Hyeong Seok, Kim, Young Sang, Kim, Ho Kyoung
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 31.10.2012
• Subjects: Allergens - immunology; Animals; Anti-inflammatory; anti-inflammatory activity; Anti-Inflammatory Agents - therapeutic use; Antigens, Dermatophagoides; atopic dermatitis; Cytokines - blood; Cytokines - genetics; Dermatitis, Atopic - blood; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - pathology; Dermatophagoides farinae - immunology; Drynaria; Drynaria fortunei; dust; dust mites; ears; ethanol; gene expression; histopathology; hyperlipidemia; IgE; IL-6; immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin G - blood; interleukin-4; interleukin-6; Male; messenger RNA; Mice; NC/Nga mouse; necrosis; Phytotherapy; Plant Extracts - therapeutic use; Polypodiaceae; Rhizome; skin lesions; traditional medicine; tumor necrosis factor-alpha; Anti-inflammatory; IgE; NC/Nga mouse; IL-6; Drynaria fortunei
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2012.08.035

Drynaria fortunei (Kunze) J. Sm has been widely used in traditional medicine for the treatment of inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and bone healing. We investigated the anti-inflammatory effects of a 70% ethanol extract of Drynaria fortunei (DFE). We evaluated the anti-inflammatory effects of topically applied DFE on house dust mite Dermatophargoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. Treatment of NC/Nga mice with DFE reduced the dermatitis score, ear thickness, and serum levels of IgE, IgG1, and IL-6. Histopathological analyses of ear and skin lesions showed inhibition of the thickening of the epidermis and reduced epidermal/dermal infiltration of inflammatory cells. In ear lesions, mRNA expression levels of IL-4, IL-6, and tumor necrosis factor-α were reduced by DFE treatment. DFE inhibited the development of dermatitis-like skin lesions in NC/Nga mice. These results suggest that DFE may be a therapeutic candidate for the treatment of AD. The anti-inflammatory and anti-allergic effects of Drynaria fortunei extract (DFE) on house dust mite Dermatophargoides farinae-induced atopic dermatitis model were evaluated by dermatitis score, ear thicknesses and histopathological analysis. DFE treatment significantly decreased the dermatitis score, ear swelling, dermis/epidermis thickening, and mast cell accumulation in the dermis of NC/Nga mice. [Display omitted]