The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 1462; p. 177
• Main Authors: Osier, Nicole, Dixon, C Edward
• Format: Journal Article
• Language: English
• Published: United States 2016
• Subjects: Animals; Brain Injuries, Traumatic - etiology; Brain Injuries, Traumatic - pathology; Cerebral Cortex - pathology; Disease Models, Animal; Mice; Primates; Rats; Research - instrumentation; Research Design; Swine; Animal model; Common data elements (CDE); Traumatic brain injury (TBI); Preclinical; Controlled cortical impact (CCI); Experimental brain injury
• ISSN: 1940-6029
• DOI: 10.1007/978-1-4939-3816-2_11

Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain trauma that uses a pneumatically or electromagnetically controlled piston to induce reproducible and well-controlled injury. The CCI model was originally used in ferrets and it has since been scaled for use in many other species. This chapter will describe the historical development of the CCI model, compare and contrast the pneumatic and electromagnetic models, and summarize key short- and long-term consequences of TBI that have been gleaned using this model. In accordance with the recent efforts to promote high-quality evidence through the reporting of common data elements (CDEs), relevant study details-that should be reported in CCI studies-will be noted.