Pandemic 2009 H1N1 Influenza A Virus Carrying a Q136K Mutation in the Neuraminidase Gene Is Resistant to Zanamivir but Exhibits Reduced Fitness in the Guinea Pig Transmission Model

• Published in: Journal of Virology Vol. 87; no. 3; pp. 1912 - 1915
• Main Authors: Kaminski, Michael M, Ohnemus, Annette, Staeheli, Peter, Rubbenstroth, Dennis
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.02.2013
• Subjects: Amino Acid Substitution; Animals; Antiviral Agents - pharmacology; Disease Models, Animal; Drug Resistance, Viral; Guinea Pigs; Influenza A virus; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza A Virus, H1N1 Subtype - physiology; Molecular Sequence Data; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation, Missense; Neuraminidase - genetics; Neuraminidase - metabolism; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; RNA, Viral - genetics; Sequence Analysis, DNA; Vaccines and Antiviral Agents; Viral Proteins - genetics; Viral Proteins - metabolism; Virulence; Virulence Factors - genetics; Virulence Factors - metabolism; Zanamivir - pharmacology
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.02507-12

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