fission yeast gene (prr1+) that encodes a response regulator implicated in oxidative stress response
An inspection of the Schizosaccharomyces pombe genome database revealed that this eukaryotic microorganism possesses a gene that may encode a bacterial type of histidine-to-aspartate (His-Asp) phosphorelay component, namely, a response regulator. The predicted gene, named prrl+ (S.pombe response reg...
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Published in | Journal of biochemistry (Tokyo) Vol. 125; no. 6; pp. 1061 - 1066 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.06.1999
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Subjects | |
Online Access | Get full text |
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Summary: | An inspection of the Schizosaccharomyces pombe genome database revealed that this eukaryotic microorganism possesses a gene that may encode a bacterial type of histidine-to-aspartate (His-Asp) phosphorelay component, namely, a response regulator. The predicted gene, named prrl+ (S.pombe response regulator), encodes a protein that contains a typical phospho-accepting receiver domain, preceded by a mammalian heat shock factor (HSF)-like DNA-binding domain. Inactivation of this prrl+ gene resulted in mutant cells defective in some aspects of stress responses, including sensitivity to oxidative stress, cold-temperature, and heavy metal toxicity. It was also demonstrated that Prrl is required for the transcription of some genes {e.g., trrl+, cttl+), which are induced by oxidative stress. These results suggest that a His-Asp phosphorelay system may be involved in a stress-activated signaling pathway in S. pombe. |
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Bibliography: | istex:26AE13A267E0754E1429E78719B341C7FC986416 This work was supported by a Grant-in-Aid (09274102) for scientific research on a priority area from the Ministry of Education, Science, Sports and Culture of Japan. ArticleID:125.6.1061 ark:/67375/HXZ-3B7SFLFK-0 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0021-924X 1756-2651 |
DOI: | 10.1093/oxfordjournals.jbchem.a022387 |