Drosophila RNAi screening in a postgenomic world

Drosophila melanogaster has a long history as a model organism with several unique features that make it an ideal research tool for the study of the relationship between genotype and phenotype. Importantly fundamental genetic principles as well as key human disease genes have been uncovered through...

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Bibliographic Details
Published inBriefings in functional genomics Vol. 10; no. 4; pp. 197 - 205
Main Author Bakal, Chris
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.2011
Subjects
Animals
Cost-Benefit Analysis
Drosophila melanogaster
Drosophila melanogaster - genetics
Genetic Testing - economics
Genetic Testing - methods
Genomics - economics
Genomics - methods
High-Throughput Screening Assays - economics
Humans
RNA Interference
Special Issue Papers
systems biology
Drosophila melanogaster
genetic interactions
RNAi, cell-based screens
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Summary:Drosophila melanogaster has a long history as a model organism with several unique features that make it an ideal research tool for the study of the relationship between genotype and phenotype. Importantly fundamental genetic principles as well as key human disease genes have been uncovered through the use of Drosophila. The contribution of the fruit fly to science and medicine continues in the postgenomic era as cell-based Drosophila RNAi screens are a cost-effective and scalable enabling technology that can be used to quantify the contribution of different genes to diverse cellular processes. Drosophila high-throughput screens can also be used as integral part of systems-level approaches to describe the architecture and dynamics of cellular networks.
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ISSN:2041-2649
2041-2647
2041-2657
DOI:10.1093/bfgp/elr015