Vitamin D and Subsequent Systolic Hypertension Among Women

• Published in: American journal of hypertension Vol. 24; no. 3; pp. 316 - 321
• Main Authors: Griffin, Flojaune C., Gadegbeku, Crystal A., Sowers, MaryFran R.
• Format: Journal Article
• Language: English
• Published: Basingstoke Oxford University Press 01.03.2011; Nature Publishing Group
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Body Mass Index; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Humans; Hypertension - etiology; Logistic Models; Longitudinal Studies; Medical sciences; Middle Aged; Systole; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - complications; blood pressure; cardiovascular disease; epidemiology; hypertension; vitamin D; Human; Hypertension; Systolic hypertension; Vitamin D; Cardiovascular disease; Arterial pressure; Blood pressure; Epidemiology
• ISSN: 0895-7061; 1879-1905; 1941-7225
• DOI: 10.1038/ajh.2010.226

Background We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25− hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). Methods The cohort includes 559 women aged 24−44 years in 1992; annual blood pressure (BP) measurements and data collection began in 1992 and is ongoing. A single-time serum 25(OH)D level was measured in 1993. Using logistic regression, vitamin D insufficiency (<80 nmol/l) was related to systolic hypertension (≥140 mm H g) measures identified in 1993 and in 2007. Further, the relationship between vitamin D at baseline and the trajectory of systolic BP across the ensuing 14 years was assessed using longitudinal mixed modeling. Results Vitamin D insufficiency was not significantly associated with concurrent systolic hypertension in 1993 (odds ratio (OR) 1.3; 95% confidence interval (CI) (0.32, 5.1)). However, vitamin D insufficiency was associated with increased risk of systolic hypertension in 2007 (OR 3.0; 95% CI (1.01, 8.7)) after adjusting for age, body fat percentage, antihypertensive medication use, and smoking. Baseline vitamin D status was not associated with rate of BP change over the 14−year period. Conclusions Consistent with previous animal and human studies, we found a single-time measure of vitamin D among young adult women was associated with systolic hypertension 14 years later. These prospective results suggest the need for further study of the role vitamin D insufficiency in early adulthood as a risk factor in subsequent hypertension among women. American Journal of Hypertension advance online publication 18 November 2010; doi:10.1038/ajh.2010.226