Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma
Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multif...
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Published in | World journal of gastroenterology : WJG Vol. 20; no. 30; pp. 10238 - 10248 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
14.08.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. |
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Bibliography: | Ashraf Ali;Hany Abdel-Hafiz;Mohd Suhail;Amany Al-Mars;Mohammad Khalid Zakaria;Kaneez Fatima;Sultan Ahmad;Esam Azhar;Adeel Chaudhary;Ishtiaq Qadri;Department of Medical Biotechnology,King Fahad Medical Research Center,King Abdul Aziz University,PO Box 80216,Jeddah 21589,Saudi Arabia;Division of Endocrinology,Department of Medicine and Metabolism,Anschutz Medical Campus,University of Colorado Denver,Aurora,CO 80045,United States;Department of Biochemistry,All India Institute of Medical Sciences,New Delhi 110029,India;IQ Institute of Infection and Immunity,Lahore 54000,Pakistan;Special Infectious Agents Unit-Biosafety Level 3,King Fahd Medical Research Center,King Abdul Aziz University,Jeddah 21589,Saudi Arabia;Medical Laboratory Technology Department,Faculty of Applied Medical Sciences,King Abdul Aziz University,Jeddah 21589,Saudi Arabia Telephone: +966-640-1000 Fax: +966-6952-5321 Author contributions: Ali A and Qadri I conceived the idea, carried out the literature search, manuscript writing and final editing; Abdel-Hafiz H edited the manuscript while Suhail M, Mars A, Sultan A and Fatima K helped in referencing, editing and figure preparation and rectifying some grammatical errors; Financial and technical assistance to Ali A and Suhail M was provided by Azhar E and Chaudhary A. Correspondence to: Ishtiaq Qadri, PhD, Professor, Head Medical Biotechnology, Head Liver Biology, Head Translational Research, Department of Medical Biotechnology, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v20.i30.10238 |