Caveats of caveolin-1 in cancer progression

• Published in: Cancer letters Vol. 268; no. 2; pp. 187 - 201
• Main Authors: Burgermeister, Elke, Liscovitch, Mordechai, Röcken, Christoph, Schmid, Roland M, Ebert, Matthias P.A
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 18.09.2008; Elsevier Limited
• Subjects: Angiogenesis; Animals; Apoptosis; Brain research; Cancer progression; Cancer therapies; Caveolin; Caveolin 1 - analysis; Caveolin 1 - physiology; Cell Adhesion; Cell Survival; Cholesterol; Disease Progression; Drug resistance; Extracellular Matrix - physiology; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; Kinases; Laboratories; Lipids; Lung cancer; Medical prognosis; Metastasis; Molecular weight; Neoplasm Metastasis; Neoplasms - etiology; Neoplasms - mortality; Neovascularization, Pathologic - etiology; Prognosis; Prostate cancer; Proteins; Cav-1 scaffolding domain; Cav-1; multidrug resistance; endothelial cells; gastrointestinal tract; Prognosis; NR; matrix metalloproteases; Metastasis; knock-out; pancreatic ductal adenocarcinoma; membrane attachment domain; Angiogenesis; adherens junction; gastric adenocarcinoma; CSD; transmembrane domain; MDR; nitric oxide synthase; GC; vascular smooth muscle cells; tight junction; EC; GI; KO; Caveolin; ZA; Cancer progression; TMD; ECM; caveolin-1; MMP; MAD; NOS; PDAC; TJ; nuclear receptor; VSMC; extracellular matrix
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2008.03.055

Abstract Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo . Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.