Impact of the Martin/Hopkins modified equation for estimating LDL-C on lipid target attainment in a high risk patient population
•We studied the performance of the Martins/Hopkins equation for estimating LDL-C in a high cardiac risk population.•This novel equation is a significant improvement over the Friedewald formula.•It remains an imperfect tool to estimate the total atherogenic load when compared to Non-HDL-C and ApoB. T...
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Published in | Clinical biochemistry Vol. 76; pp. 35 - 37 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.02.2020
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Subjects | |
Online Access | Get full text |
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Summary: | •We studied the performance of the Martins/Hopkins equation for estimating LDL-C in a high cardiac risk population.•This novel equation is a significant improvement over the Friedewald formula.•It remains an imperfect tool to estimate the total atherogenic load when compared to Non-HDL-C and ApoB.
To evaluate the Martin/Hopkins equation for estimating LDL-C as target in a population composed of high cardiac risk patients.
Lipid profile data from patients with TG ≤ 4.52 mmol/L (<400 mg/dl) were used. The high cardiac risk group (N 4150) consisted of patients over 40 years of age that had an A1C level of 6.5% or above and patients with a history of atherosclerotic cardiovascular disease (ASCVD). Comparisons were made between the Martin/Hopkins formula (MH-LDL-C), the Friedewald formula (F-LDL-C), Non-HDL-C and ApoB.
Higher LDL-C values (0.15 mmol/L or 7.3%) were obtained using MH-LDL-C compared to the F-LDL-C. The % within target (%WT) values for F-LDL-C, MH-LDL-C, Non-HDL-C and ApoB were similar when TG levels were ≤ 1.5 mmol/L with a high degree of concordance as measured by the kappa statistic. When compared to F-LDL-C, Non-HDL-C and ApoB showed a profound decrease in the WT value as TG levels increased from normal (67.7%) to intermediate (39.1%) and high levels (20.8%). MH-LDL-C showed an attenuated decrease in the WT value as TG increased from normal (61.4%) intermediate (43.4%) and high levels (32.7%). Concordance with the alternate target parameters was higher for MH-LDL-C than for F-LDL-C when triglycerides levels were increased.
The Martin/Hopkins modified equation for estimating LDL-C is a significant improvement on the decade’s old Friedewald formula; however it remains an imperfect tool to estimate the atherogenic load in patients with high TG levels. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0009-9120 1873-2933 |
DOI: | 10.1016/j.clinbiochem.2019.12.002 |