Effect of liver regeneration on malignant hepatic tumors

Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth,leading to liver tumor recurrence.Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling...

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Published inWorld journal of gastroenterology : WJG Vol. 20; no. 43; pp. 16167 - 16177
Main Authors Shi, Ji-Hua, Line, Pål-Dag
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 21.11.2014
Subjects
Animals
cancer
carcinoma
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Catheter Ablation - adverse effects
Cell Proliferation
Colorectal
Colorectal Neoplasms - pathology
Hepatectomy - adverse effects
Hepatocellular
Humans
Liver Neoplasms - metabolism
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Liver Regeneration
Neoplasm Micrometastasis
Neoplasm Recurrence, Local
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Recurre
Review
Risk Assessment
Risk Factors
Signal Transduction
Time Factors
Treatment Outcome
Tumor Microenvironment
Epithelial to mesenchymal transition
Recurrence
Hepatocellular carcinoma
Liver regeneration
Colorectal cancer
Hepatic progenitor cell
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Summary:Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth,leading to liver tumor recurrence.Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways,where activation and proliferation of mature hepatocytes,hepatic progenitor cells,non-parenchymal liver cells might favor both liver regeneration and tumor growth.This review highlights recent advances of tumor growth and development in the regenerating liver,possible mechanisms and clinical implications.
Bibliography:Ji-Hua Shi;P?l-Dag Line;Department of Transplantation Medicine,Institute for Surgical Research,Oslo University Hospital,Postboks 4950,Nydalen 0424,Oslo,Norway
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Correspondence to: Pål-Dag Line, MD, PhD, FEBS (Tx), Chairman, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway. p.d.line@medisin.uio.no
Telephone: +47-23-070509 Fax: +47-23-070510
Author contributions: Shi JH and Line PD contributed equally to this work; Shi JH and Line PD designed the review and performed the literature review; Shi JH wrote the manuscript; Line PD provided substantive revisions; all authors approved the final version of the manuscript.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i43.16167