Neuropsychological and neuropathological observations of a long-studied case of memory impairment

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 47; pp. 29883 - 29893
• Main Authors: Squire, Larry R., Kim, Soyun, Frascino, Jennifer C., Annese, Jacopo, Bennett, Jeffrey, Insausti, Ricardo, Amaral, David G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.11.2020
• Subjects: Adult; Amnesia; Amnesia, Retrograde - diagnosis; Amnesia, Retrograde - etiology; Amnesia, Retrograde - pathology; Amnesia, Retrograde - physiopathology; Amygdala; Atrophy; Basal ganglia; Biological Sciences; Brain Damage, Chronic - diagnosis; Brain Damage, Chronic - etiology; Brain Damage, Chronic - pathology; Brain Damage, Chronic - physiopathology; Cerebellum; Cerebral cortex; Cortex (entorhinal); Cortex (temporal); Damage; Dentate gyrus; Diencephalon; Diencephalon - pathology; Diencephalon - physiopathology; Epilepsy; Ganglia; Granule cells; Heart; Heart Arrest - complications; Hippocampus; Humans; Hypothalamus; Impairment; Male; Middle Aged; Neuropathology; Neuropsychological Tests; Nuclei (cytology); Pulvinar; Retrograde amnesia; Seizures; Severity of Illness Index; Single-Case Studies as Topic; Temporal lobe; Temporal Lobe - pathology; Temporal Lobe - physiopathology; Thalamus; hippocampus; diencephalon; amnesia
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2018960117

We report neuropsychological and neuropathological findings for a patient (A.B.), who developed memory impairment after a cardiac arrest at age 39. A.B. was a clinical psychologist who, although unable to return to work, was an active participant in our neuropsychological studies for 24 y. He exhibited a moderately severe and circumscribed impairment in the formation of longterm, declarative memory (anterograde amnesia), together with temporally graded retrograde amnesia covering ∼5 y prior to the cardiac arrest. More remote memory for both facts and autobiographical events was intact. His neuropathology was extensive and involved the medial temporal lobe, the diencephalon, cerebral cortex, basal ganglia, and cerebellum. In the hippocampal formation, there was substantial cell loss in the CA1 and CA3 fields, the hilus of the dentate gyrus (with sparing of granule cells), and the entorhinal cortex. There was also cell loss in the CA2 field, but some remnants remained. The amygdala demonstrated substantial neuronal loss, particularly in its deep nuclei. In the thalamus, there was damage and atrophy of the anterior nuclear complex, the mediodorsal nucleus, and the pulvinar. There was also loss of cells in the medial and lateral mammillary nuclei in the hypothalamus. We suggest that the neuropathology resulted from two separate factors: the initial cardiac arrest (and respiratory distress) and the recurrent seizures that followed, which led to additional damage characteristic of temporal lobe epilepsy.