Topiramate effectiveness in Prader-Willi syndrome

• Published in: Pediatric neurology Vol. 28; no. 2; pp. 130 - 133
• Main Authors: Smathers, Sarah A, Wilson, Jacquelyn G, Nigro, Michael A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2003; Elsevier
• Subjects: Adolescent; Affect - drug effects; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Biological and medical sciences; Child; Compulsive Behavior - drug therapy; Compulsive Behavior - etiology; Feeding Behavior - drug effects; Female; Fructose - administration & dosage; Fructose - adverse effects; Fructose - analogs & derivatives; Humans; Male; Medical sciences; Miscellaneous; Neuropharmacology; Pharmacology. Drug treatments; Prader-Willi Syndrome - complications; Prader-Willi Syndrome - drug therapy; Satiety Response - drug effects; Topiramate; Treatment Outcome; Weight Loss - drug effects; Endocrinopathy; Human; Topiramate; Prognosis; Diseases of the osteoarticular system; Male; Weight gain; Genetic disease; Case study; Chemotherapy; Mood; Treatment; Adolescent; Satiety; Female; Behavior; Complex syndrome; Child; Prader Labhart Willi syndrome
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/S0887-8994(02)00490-3

Prader-Willi syndrome is a neurologic disorder caused by a mutation on chromosome 15. It is characterized by short stature, obesity, mild-to-moderate mental retardation, and multiple behavior problems including mood, self-abusive behavior, and compulsive-eating disorder. These behaviors have detrimental effects on the mental and physical health of patients with Prader-Willi syndrome. This study evaluates the effectiveness of a new antiepileptic medication, topiramate, on behavior, mood, and compulsive-eating disorder associated with Prader-Willi syndrome. Recent studies have indicated that topiramate affects behavior, as well as reducing appetite and weight in some patients. We evaluated seven patients with Prader-Willi syndrome and determined that, in these patients, topiramate appeared to have a positive effect on reducing self-abusive behavior, improving mood, and stabilizing weight.