Liver Protein Synthesis after Partial Hepatectomy and Acute Stress

Partial hepatectomy and acute stress (intraperitoneal injection of Celite) cause increases in the rates of synthesis of serum albumin and fibrinogen, proteins that are formed mainly or entirely by the liver. The rises in protein synthesis after removal of part of the liver differ kinetically from th...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 242; no. 4; pp. 700 - 704
Main Authors Majumdar, C, Tsukada, K, Lieberman, I
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 25.02.1967
Subjects
Adrenalectomy
Animals
Fibrinogen - biosynthesis
Hepatectomy
Leucine - metabolism
Liver - metabolism
Portal Vein - surgery
Protein Biosynthesis
Puromycin - pharmacology
Rats
Ribosomes - metabolism
Serum Albumin - biosynthesis
Silicon Dioxide - pharmacology
Stress, Physiological
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Summary:Partial hepatectomy and acute stress (intraperitoneal injection of Celite) cause increases in the rates of synthesis of serum albumin and fibrinogen, proteins that are formed mainly or entirely by the liver. The rises in protein synthesis after removal of part of the liver differ kinetically from those after acute stress. In addition, only the response to partial hepatectomy is independent of the adrenal glands. Both responses seem to be related to an increase in the ability of liver polyribosomes to form protein.
ISSN:0021-9258
1083-351X
DOI:10.1016/s0021-9258(18)96261-7