A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib

Introduction: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation: The authors describe an extremely rare case of a primary spinal AT/RT that occurred i...

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Published inChild's nervous system Vol. 31; no. 9; pp. 1621 - 1623
Main Authors Gotti, Giacomo, Biassoni, Veronica, Schiavello, Elisabetta, Spreafico, Filippo, Antonelli, Manila, Calareso, Giuseppina, Pecori, Emilia, Gandola, Lorenza, Massimino, Maura
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2015
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Summary:Introduction: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-015-2755-x