Survival analysis of a prospective multicenter observational study on surgical palliation among patients with malignant bowel obstruction caused by peritoneal dissemination of gastric cancer

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 25; no. 2; pp. 422 - 429
• Main Authors: Kawabata, Ryohei, Fujitani, Kazumasa, Sakamaki, Kentaro, Ando, Masahiko, Ito, Yuichi, Tanizawa, Yutaka, Yamada, Takanobu, Hirao, Motohiro, Yamada, Makoto, Hihara, Jun, Ryoji, Fukushima, Choda, Yasuhiro, Kodera, Yasuhiro, Teshima, Shin, Shinohara, Hisashi, Kondo, Masato, Yoshida, Kazuhiro
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.03.2022; Springer Nature B.V
• Subjects: Abdominal Surgery; C-reactive protein; Cancer Research; Chemotherapy; Food intake; Gastric cancer; Gastric Outlet Obstruction - etiology; Gastroenterology; Humans; Ileostomy; Intestinal obstruction; Medical prognosis; Medicine; Medicine & Public Health; Multivariate analysis; Observational studies; Oncology; Original Article; Ostomy; Palliation; Palliative Care - methods; Patients; Peritoneum; Prospective Studies; Quality of Life; Retrospective Studies; Small intestine; Stomach Neoplasms - complications; Stomach Neoplasms - surgery; Surgery; Surgical Oncology; Survival; Survival Analysis; Palliative surgery; Malignant bowel obstruction; Gastric cancer; Survival
• ISSN: 1436-3291; 1436-3305
• DOI: 10.1007/s10120-021-01251-z

Background Our previous report showed that surgical palliation maintained quality of life (QOL), improved solid food intake, and had an acceptable surgical safety among patients with malignant bowel obstruction (MBO) caused by advanced gastric cancer. This study performed a survival analysis stratified by the patients’ QOL to elucidate its impact on survival. Methods Patients who underwent resection or bypass of the small intestine/colon or ileostomy/colostomy for bowel obstruction caused by peritoneal dissemination of gastric cancer were included. Validated instruments (EuroQoL-5 Dimensions) were used to assess QOL at baseline and 2 weeks, 1 month, and 3 months following surgical palliation. Postoperative improvement in oral intake was also evaluated using the Gastric Outlet Obstruction Scoring System (GOOSS). Univariate and multivariate survival analyses were performed using baseline characteristics and changes in QOL and GOOSS scores 2 weeks after surgery to determine prognostic factors. Results We enrolled 60 patients with a median survival time of 6.64 (95% CI 4.76–10.28) months. Patients who received postoperative chemotherapy and had lower baseline C-reactive protein (CRP) levels, higher baseline albumin levels, better baseline EuroQoL-5 Dimensions (EQ-5D) scores, and improved oral intake after palliative surgery exhibited significantly better survival. Multivariate analysis identified postoperative chemotherapy, lower baseline CRP levels, and improved oral intake as independent prognostic factors. Conclusions The current study revealed that baseline QOL and postoperative QOL changes did not affect survival. Moreover, improved oral intake, lower baseline CRP levels, and postoperative chemotherapy were significant prognostic factors in patients who underwent palliative surgery for advanced gastric cancer with MBO.