Univalent Arsanilic Acid Derivatives as Elicitors of Passive Cutaneous Anaphylaxis

Abstract A number of monovalent p-azobenzenearsonate derivatives of tyrosine elicit passive cutaneous anaphylaxis (PCA) reactions in guinea pigs sensitized with some, but not all, rabbit or guinea pig antisera raised by immunization with haptenated protein. Our data suggest that certain populations...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 107; no. 4; pp. 1175 - 1179
Main Authors Rosenberg, Leon T, Amkraut, Alfred A, Corp, Richard B, Raffel, Sidney
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.10.1971
Subjects
Animals
Antigen-Antibody Reactions
Arsenicals
Chromatography, DEAE-Cellulose
Dinitrophenols
Haptens
Hemocyanins
Immune Sera
Ovalbumin
Passive Cutaneous Anaphylaxis
Rabbits
Serum Albumin, Bovine
Tyrosine
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Summary:Abstract A number of monovalent p-azobenzenearsonate derivatives of tyrosine elicit passive cutaneous anaphylaxis (PCA) reactions in guinea pigs sensitized with some, but not all, rabbit or guinea pig antisera raised by immunization with haptenated protein. Our data suggest that certain populations of cell-binding antibodies mediate these reactions. Reversibility of antibody-hapten interaction is indicated by failure of an eliciting injection of hapten to desensitize a site. In two hapten systems so far studied, this one and a series of dinitrophenylated compounds, certain monovalent antigens were found to be capable of eliciting cutaneous anaphylactic reactions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.107.4.1175