Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report

• Published in: Heart and Vessels Vol. 18; no. 2; pp. 100 - 102
• Main Authors: Umemoto, Seiji, Itagaki, Kazuo, Kimura, Masahiro, Itoh, Shinichi, Tanaka, Masakazu, Haraguchi, Masahiko, Matsuzaki, Masunori
• Format: Journal Article
• Language: English
• Published: Japan Springer Science and Business Media LLC 01.05.2003; Springer Nature B.V
• Subjects: Acute Disease; Adult; Anti-Allergic Agents; Anti-Allergic Agents - administration & dosage; Anti-Allergic Agents - pharmacology; Anti-Inflammatory Agents; Anti-Inflammatory Agents - administration & dosage; Arylsulfonates; Arylsulfonates - administration & dosage; Arylsulfonates - pharmacology; Cardiology; Case studies; Cytokines; Drug Administration Schedule; Drug therapy; Drug Therapy, Combination; Eosinophils; Eosinophils - drug effects; Female; Heart; Humans; Interleukin-4; Interleukin-4 - antagonists & inhibitors; Medical treatment; Myocarditis; Myocarditis - blood; Myocarditis - drug therapy; Myocarditis - immunology; Myocarditis - pathology; Prednisolone; Prednisolone - administration & dosage; Sulfonium Compounds; Sulfonium Compounds - administration & dosage; Sulfonium Compounds - pharmacology; Th2 Cells; Th2 Cells - drug effects; Th2 Cells - immunology; Time Factors
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s10380-002-0689-2

We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient's inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.