Photophysical characterization and fluorescence cell imaging applications of 4- N -substituted benzothiadiazoles

In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various -substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlati...

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Published inRSC advances Vol. 12; no. 23; pp. 14544 - 14550
Main Authors Doloczki, Susanne, Holmberg, Karl O, Fdez Galván, Ignacio, Swartling, Fredrik J, Dyrager, Christine
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 12.05.2022
The Royal Society of Chemistry
Subjects
Chemistry
Droplets
Fluorescent indicators
Lipids
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Summary:In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various -substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log  ≥ 4 being characteristic for lipid droplet accumulation.
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content type line 23
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra01404a