Photophysical characterization and fluorescence cell imaging applications of 4- N -substituted benzothiadiazoles
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various -substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlati...
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Published in | RSC advances Vol. 12; no. 23; pp. 14544 - 14550 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
12.05.2022
The Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various
-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log
≥ 4 being characteristic for lipid droplet accumulation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d2ra01404a |