Coupling relationship between glucose and oxygen metabolisms to differentiate preclinical Alzheimer's disease and normal individuals

• Published in: Human brain mapping Vol. 42; no. 15; pp. 5051 - 5062
• Main Authors: Ding, Changchang, Du, Wenying, Zhang, Qi, Wang, Luyao, Han, Ying, Jiang, Jiehui
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.10.2021
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Biomarkers; Biomarkers - metabolism; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain - physiopathology; Brain mapping; Cognitive ability; Connectome; Coupling; default mode network; Default Mode Network - diagnostic imaging; Default Mode Network - metabolism; Default Mode Network - physiopathology; Dementia; Female; Fluorine isotopes; Fluorodeoxyglucose F18 - pharmacokinetics; Functional magnetic resonance imaging; Glucose; Glucose - metabolism; Homogeneity; Humans; Magnetic Resonance Imaging; Male; Medical imaging; Metabolism; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - metabolism; Nerve Net - physiopathology; Neurodegenerative diseases; Neuropsychology; Oxygen - metabolism; position emission tomography; Positron emission; Positron emission tomography; preclinical Alzheimer's disease; Radiopharmaceuticals - pharmacokinetics; Tomography; Windows (intervals); Canada; Montreal Quebec Canada; position emission tomography; default mode network; preclinical Alzheimer's disease; functional magnetic resonance imaging
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.25599

The discovery of preclinical Alzheimer's disease (preAD) provides a wide time window for the early intervention of AD. The coupling relationships between glucose and oxygen metabolisms from hybrid PET/MRI can provide complementary information on the brain's physiological state for preAD. In this study, we purpose to explore the change of coupling relationship among 27 normal controls (NCs), 20 preADs, and 15 cognitive impairments (CIs). For each subject, we calculated the Spearman partial correlation between the fractional amplitude of low‐frequency fluctuations (fALFF) and the regional homogeneity (ReHo) from functional image (fMRI), and the standard uptake value ratio (SUVR) from [18F] fluorodeoxyglucose positron emission tomography (18F‐FDG PET), in the whole‐brain and default mode network (DMN) as a novel potential biomarker. The diagnostic performance of this biomarker was evaluated by the receiver operating characteristic analysis. Significant Spearman correlations between the FDG SUVR and the fALFF/ReHo were found in 98% of subjects. For the DMN‐based biomarker, there was a significant decreasing trend for the preAD and CI groups compared to the NC group, whereas no significant difference in preAD based on whole‐brain. The correlation ρ value for the FDG SUVR/ReHo showed the highest area under curve of the preAD classification (0.787). The results imply the coupling relationship changed during the preAD stage in the DMN area. The coupling relationships between glucose and oxygen metabolisms from hybrid PET/MRI can provide complementary information on the brain's physiological state for preAD. In this study, we purpose to explore the change of coupling relationship among 27 normal controls (NCs), 20 preADs, and 15 cognitive impairments (CIs). For the DMN‐based biomarker, there was a significant decreasing trend for the preAD and CI groups compared to the NC group, whereas no significant difference in preAD based on whole‐brain.