The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes

Aim To compare the impact of two long‐term weight‐maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) or moderate intensity physical activity (PA), on the incidence of type 2 diabetes (...

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Published inDiabetes, obesity & metabolism Vol. 23; no. 2; pp. 324 - 337
Main Authors Raben, Anne, Vestentoft, Pia Siig, Brand‐Miller, Jennie, Jalo, Elli, Drummen, Mathjis, Simpson, Liz, Martinez, J. Alfredo, Handjieva‐Darlenska, Teodora, Stratton, Gareth, Huttunen‐Lenz, Maija, Lam, Tony, Sundvall, Jouko, Muirhead, Roslyn, Poppitt, Sally, Ritz, Christian, Pietiläinen, Kirsi H., Westerterp‐Plantenga, Margriet, Taylor, Moira A., Navas‐Carretero, Santiago, Handjiev, Svetoslav, McNarry, Melitta A., Hansen, Sylvia, Råman, Laura, Brodie, Shannon, Silvestre, Marta P., Adam, Tanja C., Macdonald, Ian A., San‐Cristobal, Rodrigo, Boyadjieva, Nadka, Mackintosh, Kelly A., Schlicht, Wolfgang, Liu, Amy, Larsen, Thomas M., Fogelholm, Mikael
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2021
Wiley Subscription Services, Inc
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Summary:Aim To compare the impact of two long‐term weight‐maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) or moderate intensity physical activity (PA), on the incidence of type 2 diabetes (T2D) after rapid weight loss. Materials and Methods A 3‐year multicentre randomized trial in eight countries using a 2 x 2 diet‐by‐PA factorial design was conducted. Eight‐week weight reduction was followed by a 3‐year randomized weight‐maintenance phase. In total, 2326 adults (age 25‐70 years, body mass index ≥ 25 kg/m2) with prediabetes were enrolled. The primary endpoint was 3‐year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1c and body weight. Results The total number of T2D cases was 62 and the cumulative incidence rate was 3.1%, with no significant differences between the two diets, PA or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Significantly fewer participants achieved normoglycaemia in the HP compared with the MP group (P < .0001). At 3 years, normoglycaemia was lowest in HP‐HI (11.9%) compared with the other three groups (20.0%‐21.0%, P < .05). There were no group differences in body weight change (−11% after 8‐week weight reduction; −5% after 3‐year weight maintenance) or in other secondary outcomes. Conclusions Three‐year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating and PA was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.
Bibliography:Funding information
Biotechnology and Biological Sciences Research Council (BBSRC) (UK); The Cambridge Weight Plan ©, Ltd, Northants (UK); Emil Aaltosen Säätiö; Engineering and Physical Sciences Research Council (EPSRC) (UK); EU Framework programme 7, Grant/Award Number: 312057; Finnish Diabetes Research Foundation; Government Research Funds for Helsinki University Hospital; Jenny ja Antti Wihurin Rahasto; Juho Vainio Foundation (FIN), Academy of Finland, Grant/Award Numbers: 272376, 314383, 266286, 314135; National Health and Medical Research Council ‐ EU collaborative grant, AUS 8, ID 1067711; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Novo Nordisk Fonden; Nutritics (Dublin, IRE); Signe ja Ane Gyllenbergin Säätiö; Suomen Lääketieteen Säätiö; The Danish Agriculture & Food Council; The Danish Meat and Research Institute; The Glycemic Index Foundation Australia; The NZ Health Research Council (14/191) and University of Auckland Faculty Research Development Fund
Funding information The Cambridge Weight Plan ©, Ltd, Northants (UK); Emil Aaltosen Säätiö; Engineering and Physical Sciences Research Council (EPSRC) (UK); EU Framework programme 7, Grant/Award Number: 312057; Finnish Diabetes Research Foundation; Government Research Funds for Helsinki University Hospital; Jenny ja Antti Wihurin Rahasto; Juho Vainio Foundation (FIN), Academy of Finland, Grant/Award Numbers: 272376, 314383, 266286, 314135; National Health and Medical Research Council ‐ EU collaborative grant, AUS 8, ID 1067711; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Novo Nordisk Fonden; Nutritics (Dublin, IRE); Signe ja Ane Gyllenbergin Säätiö; Suomen Lääketieteen Säätiö; The Danish Agriculture & Food Council; The Danish Meat and Research Institute; The Glycemic Index Foundation Australia; The NZ Health Research Council (14/191) and University of Auckland Faculty Research Development Fund
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.14219