Transfusion of pathogen‐reduced platelet components without leukoreduction

• Published in: Transfusion (Philadelphia, Pa.) Vol. 59; no. 6; pp. 1953 - 1961
• Main Authors: Sim, Joycelyn, Tsoi, Wai Chiu, Lee, Cheuk Kwong, Leung, Rock, Lam, Clarence C. K., Koontz, Claudia, Liu, Amy Yingjie, Huang, Norman, Benjamin, Richard J, Vermeij, Hans J., Stassinopoulos, Adonis, Corash, Laurence, Lie, Albert K. W.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2019; Wiley Subscription Services, Inc
• Subjects: Adult; Antisepsis - methods; Bacteria; Blood Platelets - cytology; Blood-Borne Pathogens - isolation & purification; Case-Control Studies; Cohort Studies; Complications; Cytomegalovirus; Disinfection - methods; Female; Furocoumarins; Gamma irradiation; Gamma Rays; Graft vs Host Disease - epidemiology; Graft vs Host Disease - etiology; Graft-versus-host reaction; Health risks; Hematopoietic stem cells; Humans; Infections; Infectious diseases; Irradiation; Isoimmunization; Leukocyte Count; Leukocytes - cytology; Male; Middle Aged; Mortality; Pathogens; Patients; Platelet Transfusion - adverse effects; Platelet Transfusion - methods; Platelet Transfusion - standards; Platelets; Screening; Stem cell transplantation; Stem cells; Thermal resistance; Transfusion; Transfusion Medicine; Transfusion Reaction - blood; Transfusion Reaction - epidemiology; Transfusion Reaction - prevention & control; Ultraviolet Rays; Virus Inactivation - drug effects; Virus Inactivation - radiation effects

BACKGROUND Leukoreduction (LR) of platelet concentrate (PC) has evolved as the standard to mitigate risks of alloimmunization, clinical refractoriness, acute transfusion reactions (ATRs), and cytomegalovirus infection, but does not prevent transfusion‐associated graft‐versus‐host disease (TA‐GVHD)....