Alcohol consumption behaviors and neurocognitive dysfunction and emotional distress in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

• Published in: Addiction (Abingdon, England) Vol. 114; no. 2; pp. 226 - 235
• Main Authors: Brinkman, Tara M., Lown, E. Anne, Li, Chenghong, Tonning Olsson, Ingrid, Marchak, Jordan Gilleland, Stuber, Margaret L., Vuotto, Stefanie, Srivastava, Deokumar, Nathan, Paul C., Leisenring, Wendy M., Armstrong, Gregory T., Robison, Leslie L., Krull, Kevin R.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2019
• Subjects: Adolescents; Adult; Adult Survivors of Child Adverse Events - psychology; Adults; Affective Symptoms - etiology; Age; Alcohol; Alcohol Drinking - adverse effects; Alcohol Drinking - psychology; Alcohol use; Alcoholic beverages; Anxiety; Behavior; Cancer; Cancer Survivors - psychology; Cancer therapies; Child; Childhood; childhood cancer; Children; Clinical outcomes; Cognition; Cognition & reasoning; Cognition Disorders - etiology; Cohort analysis; Deviation; Drinking; Drinking behavior; Emotional distress; Emotions; Emotions - physiology; Epidemiologic Methods; Female; Health risk assessment; Health status; Humans; Impairment; Intoxication; late effects; Male; Medical diagnosis; Memory; Mental depression; Neurocognition; Neurological disorders; Post traumatic stress disorder; Psychological Distress; Questionnaires; Radiation; Radiation therapy; Somatization; Survivor; survivorship; Symptoms; Teenagers; survivorship; Alcohol; childhood cancer; neurocognition; late effects; emotional distress
• ISSN: 0965-2140; 1360-0443
• DOI: 10.1111/add.14439

Aims To estimate the level of alcohol consumption behaviors in adult survivors of childhood cancer and to test associations between alcohol consumption behaviors and symptoms of neurocognitive impairment and emotional distress. Design Retrospective cohort study with longitudinal follow‐up of self‐reported health outcomes. Setting Childhood Cancer Survivor Study (CCSS), a 26‐center study of ≥ 5‐year survivors of childhood cancer diagnosed ≤ 21 years of age between 1970 and 1986 in the United States and Canada. Participants A total of 4484 adult survivors of childhood cancer [mean (standard deviation) age at evaluation = 34.8 (6.1) years; time from diagnosis = 24.8 (4.4) years] and 1651 sibling controls who completed surveys reporting on alcohol use, neurocognitive impairment and emotional distress. Measurements Survivor report of alcohol use included age at drinking initiation and quantity and frequency of alcohol consumption. Neurocognition was assessed using the CCSS Neurocognitive Questionnaire. Emotional distress symptoms were measured using the Brief Symptoms Inventory–18 and the Posttraumatic Stress Diagnostic Scale. Findings After adjustment for childhood cancer treatment exposures, including cranial radiation therapy, drinking initiation prior to 18 years of age was associated with 30% increased risk of subsequent memory problems [risk ratio (RR) = 1.3; 95% confidence interval (CI) = 1.1–1.5]. Younger age at drinking initiation was associated with future risk of depression (RR = 1.3; 95% CI = 1.1–1.5), anxiety (RR = 1.6; 95% CI = 1.3–2.1), and somatization (RR = 1.2; 95% CI = 1.1–1.4). Persistent heavy/risky drinking was associated with 80% increased risk of persistent psychological distress (RR = 1.8, 95% CI = 1.4–2.3). Conclusions Drinking initiation during adolescence is associated with modest increased risk for memory impairment and emotional distress in adult survivors of childhood cancer.