Functional connectivity gradients of the insula to different cerebral systems

• Published in: Human brain mapping Vol. 44; no. 2; pp. 790 - 800
• Main Authors: Wang, Rui, Mo, Fan, Shen, Yuhao, Song, Yu, Cai, Huanhuan, Zhu, Jiajia
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2023
• Subjects: Alzheimer's disease; Brain; Brain Mapping; Cerebral Cortex - diagnostic imaging; Contraindications; Datasets; functional connectivity gradients; Functional magnetic resonance imaging; Functionally gradient materials; Head injuries; hierarchical organization; Humans; insula; Insular Cortex; Magnetic Resonance Imaging; Neural networks; Neural Pathways - diagnostic imaging; Parietal Lobe; resting‐state functional MRI; functional connectivity gradients; hierarchical organization; insula; resting-state functional MRI
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.26099

The diverse functional roles of the insula may emerge from its heavy connectivity to an extensive network of cortical and subcortical areas. Despite several previous attempts to investigate the hierarchical organization of the insula by applying the recently developed gradient approach to insula‐to‐whole brain connectivity data, little is known about whether and how there is variability across connectivity gradients of the insula to different cerebral systems. Resting‐state functional MRI data from 793 healthy subjects were used to discover and validate functional connectivity gradients of the insula, which were computed based on its voxel‐wise functional connectivity profiles to distinct cerebral systems. We identified three primary patterns of functional connectivity gradients of the insula to distinct cerebral systems. The connectivity gradients to the higher‐order transmodal associative systems, including the prefrontal, posterior parietal, temporal cortices, and limbic lobule, showed a ventroanterior‐dorsal axis across the insula; those to the lower‐order unimodal primary systems, including the motor, somatosensory, and occipital cortices, displayed radiating transitions from dorsoanterior toward both ventroanterior and dorsoposterior parts of the insula; the connectivity gradient to the subcortical nuclei exhibited an organization along the anterior–posterior axis of the insula. Apart from complementing and extending previous literature on the heterogeneous connectivity patterns of insula subregions, the presented framework may offer ample opportunities to refine our understanding of the role of the insula in many brain disorders. Resting‐state functional MRI data from 793 healthy subjects were used to discover and validate functional connectivity gradients of the insula, which were computed based on its voxel‐wise functional connectivity profiles to distinct cerebral systems. We identified three primary patterns of functional connectivity gradients of the insula to distinct cerebral systems.