Pericytes modulate myelination in the central nervous system

• Published in: Journal of cellular physiology Vol. 233; no. 8; pp. 5523 - 5529
• Main Authors: Azevedo, Patrick O., Sena, Isadora F.G., Andreotti, Julia P., Carvalho‐Tavares, Juliana, Alves‐Filho, José C., Cunha, Thiago M., Cunha, Fernando Q., Mintz, Akiva, Birbrair, Alexander
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2018
• Subjects: Autoimmune diseases; Brain; Central nervous system; Demyelination; Glial stem cells; Molecular modelling; Multiple sclerosis; Myelin; Myelination; Nervous system; Pericytes; Regeneration; Rodents; myelination; multiple sclerosis; pericytes; central nervous system

Multiple sclerosis is a highly prevalent chronic demyelinating disease of the central nervous system. Remyelination is the major therapeutic goal for this disorder. The lack of detailed knowledge about the cellular and molecular mechanisms involved in myelination restricts the design of effective tr...