Pericytes modulate myelination in the central nervous system

Multiple sclerosis is a highly prevalent chronic demyelinating disease of the central nervous system. Remyelination is the major therapeutic goal for this disorder. The lack of detailed knowledge about the cellular and molecular mechanisms involved in myelination restricts the design of effective tr...

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Bibliographic Details
Published inJournal of cellular physiology Vol. 233; no. 8; pp. 5523 - 5529
Main Authors Azevedo, Patrick O., Sena, Isadora F.G., Andreotti, Julia P., Carvalho‐Tavares, Juliana, Alves‐Filho, José C., Cunha, Thiago M., Cunha, Fernando Q., Mintz, Akiva, Birbrair, Alexander
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.08.2018
Subjects
Autoimmune diseases
Brain
Central nervous system
Demyelination
Glial stem cells
Molecular modelling
Multiple sclerosis
Myelin
Myelination
Nervous system
Pericytes
Regeneration
Rodents
myelination
multiple sclerosis
pericytes
central nervous system
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Summary:Multiple sclerosis is a highly prevalent chronic demyelinating disease of the central nervous system. Remyelination is the major therapeutic goal for this disorder. The lack of detailed knowledge about the cellular and molecular mechanisms involved in myelination restricts the design of effective treatments. A recent study by using [De La Fuente et al. (2017) Cell Reports, 20(8): 1755‐1764] by using state‐of‐the‐art techniques, including pericyte‐deficient mice in combination with induced demyelination, reveal that pericytes participate in central nervous system regeneration. Strikingly, pericytes presence is essential for oligodendrocyte progenitors differentiation and myelin formation during remyelination in the brain. The emerging knowledge from this research will be important for the treatment of multiple sclerosis. Central nervous system pericytes react to demyelination, and stimulate oligodendrocyte progenitors differentiation.
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ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26348