Polychlorinated dibenzo‐p‐dioxins and dibenzofurans levels in piglet liver with various diseases

• Published in: International journal of experimental pathology Vol. 98; no. 4; pp. 214 - 220
• Main Authors: Shin, Jeoung Hwa, Ji, Won Hyun, Chae, Chanhee, Gorinstein, Shela, Ahn, Yun Gyong
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2017; John Wiley and Sons Inc
• Subjects: Animals; bacillus nature diseases; Bacteria; Benzofurans - pharmacology; Chemical and Drug Induced Liver Injury; Congeners; Dibenzo-p-dioxin; Dilution; Dioxins; Gas chromatography; High resolution; Infectious diseases; Liver; Liver - drug effects; Liver diseases; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Original; piglet; Polychlorinated dibenzodioxins; Polychlorinated Dibenzodioxins - pharmacology; polychlorinated dibenzo‐p‐dioxins/furans; porcine reproductive and respiratory syndrome virus (PRRSV); Swine; Viral diseases; Viruses; polychlorinated dibenzo-p-dioxins/furans; piglet; bacillus nature diseases; porcine reproductive and respiratory syndrome virus (PRRSV)
• ISSN: 0959-9673; 1365-2613
• DOI: 10.1111/iep.12238

Summary This study deals with the levels of toxic polychlorinated dibenzo‐p‐dioxin and furan congeners (PCDD/Fs) in the livers of piglets affected by infectious diseases using isotope dilution high‐resolution gas chromatography/high‐resolution mass spectrometry (HRGC/HRMS). Seventeen toxic congeners in the liver samples infected with bacterial and viral diseases were compared. For porcine reproductive and respiratory syndrome virus (PRRSV) samples, the North American‐ and European‐type PRRS diseases were observed. This study shows that there are significantly different levels of PCDD/Fs, present, which vary according to the types of diseases as evidenced by our analysis of the piglet liver samples.