Community violence exposure correlates with smaller gray matter volume and lower IQ in urban adolescents

• Published in: Human brain mapping Vol. 39; no. 5; pp. 2088 - 2097
• Main Authors: Butler, Oisin, Yang, Xiao‐Fei, Laube, Corinna, Kühn, Simone, Immordino‐Yang, Mary Helen
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2018; John Wiley and Sons Inc
• Subjects: Adolescent; adolescent development; Adolescents; Aggression; Autonomic nervous system; Brain; Brain - diagnostic imaging; Brain - pathology; Cognition; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cognitive ability; Communities; Correlation analysis; Cortex (cingulate); Crime; Exposure; Exposure to Violence - psychology; Female; Females; Frontal gyrus; Gray Matter - diagnostic imaging; Health care; Humans; Illnesses; Image Processing, Computer-Assisted; Intellectual Disability - diagnostic imaging; Intellectual Disability - pathology; Intelligence; Magnetic Resonance Imaging; Male; Males; Medical imaging; Military psychology; Neuroimaging; Neurology; Neuropsychological Tests; Parents; Post traumatic stress disorder; Public health; Social Class; stress; Substantia grisea; Teenagers; Urban environments; Urban Population; Violence; voxel‐based morphometry; adolescent development; stress; post-traumatic stress disorder; voxel-based morphometry; brain
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.23988

Adolescents’ exposure to community violence is a significant public health issue in urban settings and has been associated with poorer cognitive performance and increased risk for psychiatric illnesses, including PTSD. However, no study to date has investigated the neural correlates of community violence exposure in adolescents. Sixty‐five healthy adolescents (age = 14–18 years; 36 females, 29 males) from moderate‐ to high‐crime neighborhoods in Los Angeles reported their violence exposure, parents’ education level, and free/reduced school lunch status (socio‐economic status, SES), and underwent structural neuroimaging and intelligence testing. Violence exposure negatively correlated with measures of SES, IQ, and gray matter volume. Above and beyond the effect of SES, violence exposure negatively correlated with IQ and with gray matter volume in the left inferior frontal gyrus and anterior cingulate cortex, regions involved in high‐level cognitive functions and autonomic modulation, and previously shown to be reduced in PTSD and combat‐exposed military populations. The current results provide first evidence that frontal brain regions involved in cognition and affect appear to be selectively affected by exposure to community violence, even in healthy nondelinquent adolescents who are not the direct victims or perpetrators of violence.