Abnormal resting‐state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia

• Published in: CNS neuroscience & therapeutics Vol. 24; no. 10; pp. 897 - 905
• Main Authors: Zhan, Zhou‐Wei, Lin, Li‐Zhen, Yu, Er‐Han, Xin, Jia‐Wei, Lin, Lin, Lin, Hai‐Long, Ye, Qin‐Yong, Chen, Xiao‐Chun, Pan, Xiao‐Dong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Brain mapping; Cerebellum; Cognitive ability; Cognitive Dysfunction - complications; Cognitive Dysfunction - diagnostic imaging; Cortex (cingulate); Data processing; Dementia; Dementia - complications; Dementia - diagnostic imaging; Dementia disorders; Female; functional connectivity; Functional magnetic resonance imaging; Gyrus Cinguli - diagnostic imaging; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; mild cognitive impairment; Movement disorders; Neural networks; Neurodegenerative diseases; Neuroimaging; Neuropsychological Tests; Original; Oxygen - blood; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson's disease; posterior cingulate cortex; Prefrontal cortex; Rest; resting‐state functional magnetic resonance imaging; resting-state functional magnetic resonance imaging; dementia; mild cognitive impairment; Parkinson's disease; functional connectivity; posterior cingulate cortex
• ISSN: 1755-5930; 1755-5949; 1755-5949
• DOI: 10.1111/cns.12838

Summary Objective To investigate changes in the functional connectivity (FC) pattern in the posterior cingulate cortex (PCC) of Parkinson's disease (PD) patients with mild cognitive impairment and dementia by employing resting‐state functional magnetic resonance imaging (RS‐fMRI). Methods Twenty‐seven PD patients with different cognitive status and 9 healthy control subjects (control group) were enrolled for RS‐fMRI. The RS‐fMRI data were analyzed with DPARSF and REST software. Regions with changed functional connectivity were determined by the seed‐based voxelwise method and compared between groups. Correlation between the intensity of FC and the MoCA scores of PD group was analyzed. Results Parametric maps showed statistical increases in PCC functional connectivity in PD‐MCI patients and decreases in PCC connectivity in PDD patients. The latter group of patients also showed evidence for increased connectivity between prefrontal cortices and posterior cerebellum. A significant positive correlation was found between the MoCA scores and the strength of PCC connectivity in the angular gyrus and posterior cerebellum and a negative correlation between MoCA scores and PCC connectivity in all other brain regions. Conclusion When patients transition from PD‐NCI to PD‐MCI, there appears to be an increase in functional connectivity in the PCC, suggesting an expansion of the cortical network. Another new network (a compensatory prefrontal cortical‐cerebellar loop) later develops during the transition from PD‐MCI to PDD.