Oral squamous cell carcinoma involving the maxillae: Factors affecting local recurrence and the value of salvage treatment for overall survival

• Published in: Head & neck Vol. 42; no. 8; pp. 1821 - 1828
• Main Authors: Slieker, Fons J. B., Bree, Remco, Van Cann, Ellen M.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2020; Wiley Subscription Services, Inc
• Subjects: 5‐year local control; Bone cancer; Head and neck; Jaw; malignancy; maxillary cancer; maxillectomy; Oral cancer; Oral squamous cell carcinoma; Original; Patients; salvage treatment; Squamous cell carcinoma; Surgery; maxillary cancer; 5-year local control; malignancy; maxillectomy; salvage treatment; squamous cell carcinoma
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.26108

Objective To determine factors associated with local recurrence (LR) of oral squamous cell carcinoma involving the maxillae (MSCC) and overall survival (OS) after salvage treatment. Subjects and Methods Retrospective study of MSCC operated between 2000 and 2015. Kaplan‐Meier survival and Cox regression were used for analysis of MSCC‐associated clinical and histopathological factors. Results Ninety‐five patients were included. LR occurred in 24% of patients. Vascular invasion significantly increased the risk of LR (hazard ratio 4.595, P = .003). Local salvage surgery, in the area of the original tumor, significantly prolonged OS, compared to palliative treatment (P = .001) and extensive salvage surgery (P = .013). Extensive salvage surgery, requiring resection of adjacent facial structures, did not prolong OS compared to palliative treatment (P = .186). Conclusions MSCC with vascular invasion has higher risk of LR. Salvage surgery may prolong OS in small recurrences but might have dubious value for larger recurrences infiltrating adjacent facial structures.