Human Brain Resilience: A Call to Action

At present, resilience refers to a highly heterogeneous concept with ill‐defined determinants, mechanisms, and outcomes. This call for action argues for the need to define resilience as a person‐centered multidimensional metric, informed by a dynamic lifespan perspective and combining observational...

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Published inAnnals of neurology Vol. 90; no. 3; pp. 336 - 349
Main Authors Pascual‐Leone, Alvaro, Bartres‐Faz, David
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.09.2021
Wiley Subscription Services, Inc
Subjects
Brain - physiology
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - psychology
Healthy Aging - physiology
Healthy Aging - psychology
Humans
Life span
Pandemics
Resilience
Resilience, Psychological
Viral diseases
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Summary:At present, resilience refers to a highly heterogeneous concept with ill‐defined determinants, mechanisms, and outcomes. This call for action argues for the need to define resilience as a person‐centered multidimensional metric, informed by a dynamic lifespan perspective and combining observational and interventional experimental studies to identify specific neural markers and correlated behavioral measures. The coronavirus disease 2019 (COVID‐19) pandemic highlights the urgent need of such an effort with the ultimate goal of defining a new vital sign, an individual index of resilience, as a life‐long metric with the capacity to predict an individual's risk for disability in the face of a stressor, insult, injury, or disease. ANN NEUROL 2021;90:336–349
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AP-L and DB-F have contributed equally to the conception and design of the manuscript, drafted the manuscript and reviewed and approved the content of the submitted version.
Author contributions
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.26157