Action of Sodium Deoxycholate on Subcutaneous Human Tissue: Local and Systemic Effects
BACKGROUND Phosphatidylcholine injections have been used as a nonsurgical alternative to the surgical removal of undesired fat. Studies in cell culture suggest that sodium deoxycholate (SD) has a detergent action in fat reduction. OBJECTIVE The objective was to study SD in subcutaneous human tissue....
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Published in | Dermatologic surgery Vol. 33; no. 2; pp. 178 - 189 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.02.2007
by the American Society for Dermatologic Surgery, Inc Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND
Phosphatidylcholine injections have been used as a nonsurgical alternative to the surgical removal of undesired fat. Studies in cell culture suggest that sodium deoxycholate (SD) has a detergent action in fat reduction.
OBJECTIVE
The objective was to study SD in subcutaneous human tissue.
METHODS AND MATERIALS
Thirty volunteers underwent four sessions of subcutaneous abdominal injections of diluted 2.5 or 1% SD stock solutions or placebo. Clinical, hematologic, and ultrasonographic evaluations were performed for 3 months and histology at 3 and 6 months.
RESULTS
Both concentrations of SD induced an inflammatory response at the injection site, with dose‐dependent adipocyte lysis. Patients reported mild, localized heat, erythema, swelling, and intense pain. Microscopic evaluation revealed necrosis of adipose tissue with adipocyte lysis, fat dissolution, acute lymphomononuclear inflammatory reaction, and intense phagocytosis of fat cells by macrophages. Fibrosis was observed only at the 6‐month biopsy. Nodules at the injection sites, compatible with areas of inflammation, were detected by ultrasonography 2 weeks after the first injection. Placebo injections induced no histologic changes.
CONCLUSIONS
SD induces an inflammatory reaction in subcutaneous human fat and dose‐dependent adipocyte lysis with acute pain and fibrosis. No systemic effects were detected. Further studies will establish the best dose–result ratio, frequency of application, and long‐term safety. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1076-0512 1524-4725 |
DOI: | 10.1111/j.1524-4725.2006.33036.x |