Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis‐associated chronic rhinosinusitis: A randomised pilot trial
Objectives Manuka honey attacks biofilms, which contribute to bacterial persistence in cystic fibrosis sinusitis. The primary objective was to determine feasibility of investigating manuka honey as an irrigation treatment for cystic fibrosis sinusitis and secondarily to assess the treatment's p...
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Published in | Clinical otolaryngology Vol. 46; no. 1; pp. 168 - 174 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.01.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Objectives
Manuka honey attacks biofilms, which contribute to bacterial persistence in cystic fibrosis sinusitis. The primary objective was to determine feasibility of investigating manuka honey as an irrigation treatment for cystic fibrosis sinusitis and secondarily to assess the treatment's preliminary effectiveness.
Design
Prospective, single‐blinded (clinician only), randomised, parallel two‐arm pilot trial.
Setting
Tertiary rhinology clinic.
Participants
Subjects had recalcitrant cystic fibrosis sinusitis and previous sinus surgery. They received manuka honey or saline sinus irrigations twice daily for 30 days.
Main Outcome Measures
Main outcomes were recruitment/retention rates and tolerability. Preliminary effectiveness was assessed based on quality‐of‐life Sinonasal Outcome Test‐22 and Lund‐Kennedy endoscopic change scores and post‐treatment culture negativity.
Results
Over 10 months, 13 subjects were enrolled, and 77% (10/13) were included in the analysis. Manuka honey irrigations were well‐tolerated. The quality‐of‐life change score was clinically significant for manuka honey (−9 [−14,−6]) but not saline (−5 [−9,−1]), although the difference was not statistically significant (P = .29). Lund‐Kennedy endoscopic change score was significantly better for manuka honey (−3 [−5,−3]) versus saline (0 [0,0]) (P = .006). There was no difference in post‐treatment culture negativity between manuka honey (1/5, 20%) and saline (0/5, 0%) (P = 1.00).
Conclusions
Manuka honey irrigations were well tolerated, and retention rates were high. Preliminary data showed that manuka honey achieved a clinically important difference in quality‐of‐life score and a significantly better endoscopic outcome. Microbiological control was difficult to achieve. A future definitive trial would require multi‐institutional recruitment. |
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Bibliography: | Funding information This study was presented as a poster at the Annual Meeting of the American Rhinologic Society on September 8, 2017, in Chicago, IL. This study was supported by Derma Sciences, which solely provided financial and product support. Derma Sciences was not involved in any other aspect of this study, including design, analysis and reporting of results. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 AUTHOR CONTRIBUTIONS Victoria S. Lee: Conceptualisation, methodology, software, validation, formal analysis, investigation, resources, data curation, writing—original draft, writing—review and editing, project administration. Ian M. Humphreys, Patricia L. Purcell: Data curation, writing—review and editing. Greg E. Davis: Conceptualisation, methodology, investigation, resources, data curation, writing—review and editing, project administration. |
ISSN: | 1749-4478 1749-4486 1749-4486 |
DOI: | 10.1111/coa.13637 |