Photocontrol of the Translocation of Molecules, Peptides, and Quantum Dots through Cell and Lipid Membranes Doped with Azobenzene Copolymers

Light opens: Photocontrolled transmembrane passage of soluble dyes and delivery of small peptides into mammalian cells has been achieved using azobenzene‐modified polymers (AMPs) as permeabilizing agents. Irradiation with UV and visible light triggers polarity switches upon cis–trans isomerization o...

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Published inAngewandte Chemie International Edition Vol. 51; no. 9; pp. 2132 - 2136
Main Authors Sebai, Sarra C., Milioni, Dimitra, Walrant, Astrid, Alves, Isabel D., Sagan, Sandrine, Huin, Cécile, Auvray, Loic, Massotte, Dominique, Cribier, Sophie, Tribet, Christophe
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 27.02.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Animals
Azo Compounds - chemistry
azobenzenes
Cell Membrane - metabolism
CHO Cells
Copolymers
Cricetinae
Delayed-Action Preparations - chemistry
Dyes
Isomerism
Isomerization
Light
Lipid Bilayers - metabolism
Lipids
membranes
Peptides
Peptides - administration & dosage
Permeability
photochromism
Polarity
Polymers
Polymers - chemistry
Porosity
Quantum Dots
Qunatum dots
Switches
vesicles
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Summary:Light opens: Photocontrolled transmembrane passage of soluble dyes and delivery of small peptides into mammalian cells has been achieved using azobenzene‐modified polymers (AMPs) as permeabilizing agents. Irradiation with UV and visible light triggers polarity switches upon cis–trans isomerization of the azobenzene moieties. Photoresponsive permeability and pore opening promoted by trans‐AMPs, but not cis‐AMPs, in supported lipid bilayers are observed.
Bibliography:ArticleID:ANIE201106777
This work was supported by the ANR for the award of Grant photo-channels N° ANR-07-BLAN-0278. The authors thank Déborah Cardoso for providing Figure S4 and F. Pinaud and M. Dahan for providing Qdots.
ANR - No. ANR-07-BLAN-0278
ark:/67375/WNG-3SZ6KK7M-D
istex:CCBCD7C0E439A9FC36CCF4482ABE105689DADE85
This work was supported by the ANR for the award of Grant photo‐channels N° ANR‐07‐BLAN‐0278. The authors thank Déborah Cardoso for providing Figure S4 and F. Pinaud and M. Dahan for providing Qdots.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106777