Right‐hemispheric language reorganization in patients with brain arteriovenous malformations: A functional magnetic resonance imaging study

• Published in: Human brain mapping Vol. 42; no. 18; pp. 6014 - 6027
• Main Authors: Deng, Xiaofeng, Wang, Bo, Zong, Fangrong, Yin, Hu, Yu, Shaochen, Zhang, Dong, Wang, Shuo, Cao, Yong, Zhao, Jizong, Zhang, Yan
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.12.2021
• Subjects: Adolescent; Adult; arteriovenous malformation; Auditory tasks; Brain; Brain Mapping; Cerebellum; Cerebellum - diagnostic imaging; Cerebellum - physiopathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Comprehension - physiology; Female; Frontal lobe; Functional Laterality - physiology; Functional magnetic resonance imaging; Hearing; Hemispheres; Hemispheric laterality; Humans; Intracranial Arteriovenous Malformations - diagnostic imaging; Intracranial Arteriovenous Malformations - pathology; Language; Lesions; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Neuroimaging; Precentral gyrus; Psycholinguistics; Reading; reorganization; Resonance; Speech Perception - physiology; Temporal cortex; Temporal lobe; Visual tasks; Young Adult; arteriovenous malformation; language; reorganization; functional magnetic resonance imaging
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.25666

Brain arteriovenous malformation (AVM), a presumed congenital lesion, may involve traditional language areas but usually does not lead to language dysfunction unless it ruptures. The objective of this research was to study right‐hemispheric language reorganization patterns in patients with brain AVMs using functional magnetic resonance imaging (fMRI). We prospectively enrolled 30 AVM patients with lesions involving language areas and 32 age‐ and sex‐matched healthy controls. Each subject underwent fMRI during three language tasks: visual synonym judgment, oral word reading, and auditory sentence comprehension. The activation differences between the AVM and control groups were investigated by voxelwise analysis. Lateralization indices (LIs) for the frontal lobe, temporal lobe, and cerebellum were compared between the two groups, respectively. Results suggested that the language functions of AVM patients and controls were all normal. Voxelwise analysis showed no significantly different activations between the two groups in visual synonym judgment and oral word reading tasks. In auditory sentence comprehension task, AVM patients had significantly more activations in the right precentral gyrus (BA 6) and right cerebellar lobule VI (AAL 9042). According to the LI results, the frontal lobe in oral word reading task and the temporal lobe in auditory sentence comprehension task were significantly more right‐lateralized in the AVM group. These findings suggest that for patients with AVMs involving language cortex, different language reorganization patterns may develop for different language functions. The recruitment of brain areas in the right cerebral and cerebellar hemispheres may play a compensatory role in the reorganized language network of AVM patients. The objective of this research was to study right‐hemispheric language reorganization patterns in patients with brain AVMs using functional magnetic resonance imaging (fMRI). Findings suggest that for patients with AVMs involving language cortex, different language reorganization patterns may develop for different language functions. The recruitment of brain areas in the right cerebral and cerebellar hemispheres may play a compensatory role in the reorganized language network of AVM patients.