The Association of Obesity, Type 2 Diabetes, and Hypertension with Severe Coronavirus Disease 2019 on Admission Among Mexican Patients

• Published in: Obesity (Silver Spring, Md.) Vol. 28; no. 10; pp. 1826 - 1832
• Main Authors: Denova‐Gutiérrez, Edgar, Lopez‐Gatell, Hugo, Alomia‐Zegarra, Jose L., López‐Ridaura, Ruy, Zaragoza‐Jimenez, Christian A., Dyer‐Leal, Dwigth D., Cortés‐Alcala, Ricardo, Villa‐Reyes, Tania, Gutiérrez‐Vargas, Rosaura, Rodríguez‐González, Kathia, Escondrillas‐Maya, Carlos, Barrientos‐Gutiérrez, Tonatiuh, Rivera, Juan A., Barquera, Simón
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2020; John Wiley and Sons Inc
• Subjects: Adult; Age; Age Factors; Aged; Betacoronavirus; Chronic illnesses; Coronavirus Infections - epidemiology; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID‐19 and Obesity; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - virology; Disease; Epidemiology; Female; Health surveillance; Hospitalization - statistics & numerical data; Hospitals; Humans; Hypertension; Hypertension - epidemiology; Hypertension - virology; Intensive care; Laboratories; Logistic Models; Male; Mexico - epidemiology; Middle Aged; Obesity; Obesity - epidemiology; Obesity - virology; Original; Pandemics; Patients; Pneumonia; Pneumonia, Viral - epidemiology; Pneumonia, Viral - virology; Respiratory diseases; Retrospective Studies; Risk Factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Software; Variables; Mexico
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.22946

Objective This study’s aim was to explore the association of obesity, type 2 diabetes, and hypertension with severe coronavirus disease 2019 (COVID‐19) on admission. Methods In the present study, a total of 23,593 patient samples were evaluated by a laboratory from the Mexican Institute of Epidemiological Diagnosis and Reference. Of these, 18,443 were negative for COVID‐19, 3,844 were positive for COVID‐19, and 1,306 were positive for other respiratory viruses. Severe types of respiratory disease were defined by the presence of pneumonia and other organ failure that requires intensive care. Multivariable logistic regression models were used to explore factors associated with severe COVID‐19 on admission. Results Patients who tested positive for COVID‐19 had a higher proportion of obesity (17.4%), diabetes (14.5%), and hypertension (18.9%) compared with those without a confirmed diagnosis. Compared with patients without obesity, those with obesity showed a 1.43‐fold higher odds of developing severe COVID‐19 on admission, whereas subjects with diabetes and hypertension showed a 1.87‐fold and 1.77‐fold higher odds of developing severe COVID‐19 on admission, respectively. Conclusions Obesity, diabetes, and hypertension were significantly associated with severe COVID‐19 on admission and the association of obesity was stronger in patients < 50 years of age.