The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma

• Published in: Cancer medicine (Malden, MA) Vol. 7; no. 10; pp. 5205 - 5216
• Main Authors: Wang, Lu, Li, Weiwei, Li, Kai, Guo, Yi, Liu, Ditian, Yao, Zhimeng, Lin, Xianjie, Li, Shujun, Jiang, Zuojie, Liu, Qing, Jiang, Yi, Zhang, Beien, Chen, Lei, Zhou, Fuyou, Ren, Hongzheng, Lin, Danxia, Zhang, Dianzheng, Yeung, Sai‐Ching Jim, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: Androgen receptors; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer Biology; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; coregulator; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - metabolism; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Estrogen receptors; Female; Gene Amplification; Gene expression; Gene Expression Regulation, Neoplastic; Humans; invasiveness; Male; Menopause; migration; Nuclear Receptor Coactivator 1 - genetics; Nuclear Receptor Coactivator 1 - metabolism; Original Research; Prognosis; proliferation; sex steroid receptor signaling; Squamous cell carcinoma; SRC‐1; Steroid hormone receptors; Survival Analysis; Tumor Burden; Up-Regulation; United States > US; invasiveness; coregulator; proliferation; migration; esophageal carcinoma; sex steroid receptor signaling; SRC-1
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.1786

Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. However, the clinical relevance and the functional roles of NCOA1 in human esophageal squamous cell carcinoma (ESCC) are less known. We found in this study that elevated levels of NCOA1 protein and/or mRNA as well as amplification of the NCOA1 gene occur in human ESCC. Elevated levels of NCOA1 due to these dysregulations were not only associated with more aggressive clinic‐pathologic parameters but also poorer survival. Results from multiple cohorts of ESCC patients strongly suggest that the levels of NCOA1 could serve as an independent predictor of overall survival. In addition, silencing NCOA1 in ESCC cells remarkably decreased proliferation, migration, and invasion. These findings not only indicate that NCOA1 plays important roles in human ESCC but the levels of NCOA1 also could serve as a potential prognostic biomarker of ESCC and targeting NCOA1 could be an efficacious strategy in ESCC treatment. NCOA1 plays important roles in human ESCC, but the levels of NCOA1 also could serve as a potential prognostic biomarker of ESCC and targeting NCOA1 could be an efficacious strategy in ESCC treatment.